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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
Ephedradine A |
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다른이름들 |
Orantine
3,3a,6,7,8,9,10,11,12,13,14,15-Dodecahydro-3-(4-hydroxyphenyl)-4H-1,16-etheno-5,15-(propaniminoethano)furo[3,4-l][1,5,10]triazacyclohexa-decine-4,21-dione |
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함유 천연물 |
Ephedra sinica Stapf[초마황](마황(麻黃),마황근(麻黃根)) |
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분 자 식 |
C28H36N4O4 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
492.624 |
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녹 는 점 |
216-219°C |
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생리학적효과 |
Hypertensive activity |
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굴 절 율 |
[α]D = -72°(C 2.341) |
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UV_CHART |
(λmax, nm) (EtOH):228(4.24), 281(3.54), 288 sh(3.40); (EtOH-NaOH) 245, 286 |
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HNMR_CHART |
(CD3OD,200 MHz) δ:7.31(d, 8.6, H29,33), 7.25(br s, H13), 7.15(dd, 7.9, 1, H27), 6.80(d, 8.6, H30,32), 6.79(d, 7.9, H30,32), 6.79(d, 7.9, H26), 6.03(d, 11.5, H17), 4.62(d, 11.5, H18), 4.09(dd, 13, 8, H11), 4.00-3.60, 3.04-2.46, 2.40-2.00, 1.92-1.40 |
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CNMR_CHART |
(CD3OD) δ: 171.4, 169.4, 158.1, 157.8, 134.7, 128.7, 128.4, 125.1, 127.1, 121.5, 114.8, 107.9, 87.5, 59.4, 52.7, 47.6, 46.1, 45.9, 44.7, 43.3, 41.7, 36.4, 27.6, 26.9, 25.8, 24.7 |
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MASS_CHART |
M+= 492, m/z= 449, 377, 252, 251, 238, 223, 213, 173, 148, 134, 122, 107(100), 94, 84, 71 |
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참고문헌 |
· H. Bosshardt et al., Pharm. Acta Helv., 51, 371, 1976
· P. Daetwyler et al., Helv. Chim. Acta, 62, 2717, 1979(uv,ir,pmr,ms)
· M. Tamada et al., Tetrahedron Lett., 873, 1979
· HM. Wasserman et al., J. Am. Chem. Soc., 107, 519, 1985
· VU. Ahmad et al., J. Nat. Prod., 53, 1162, 1990 |
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