코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Cytisine ((-)-form)

다른이름들 

(-)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (-)-Baptitoxine (-)- Citisine (-)-Cytiton (-)-Sophorine (-)-Ulexine

함유 천연물 

Sophora arizonica S. Wats.[-]()
Sophora chrysophylla Seem.[-]()
Sophora exigua[-]()
Sophora flavescens Solander ex Aiton[고삼(Go-sam)](고삼(苦蔘),고삼실(苦蔘實),수괴(水槐),지괴(地槐))
Sophora formosa[-]()
Sophora griffithii[-]()
Sophora gysophylla B.L. Turner & Powell[-]()
Sophora japonica L.[회화나무(Hoe-hwa-na-mu)](괴화(槐花),괴각(槐角),괴지(槐枝),괴엽(槐葉),괴각자(槐角子),괴교(槐膠),괴근백피(槐根白皮),괴백피(槐白皮),괴실(槐實),괴윤(槐潤),괴자(槐子),괴자인(槐子仁),괴조(槐條),수궁괴(守宮槐))
Sophora leachiana M.E. Peck[-]()
Sophora longesmen[-]()
Sophora macrocarpa[-]()
Sophora masafeurana[-]()
Sophora microphylla[-]()
Sophora mollis[-]()
Sophora moorcroftiana (Wall.) Benth.ex Bak.[-]()
Sophora muteliana[-]()
Sophora pachycarpa[-]()
Sophora secundiflora (Ortega) Lag.ex DC.[]()
Sophora stenophylla Gray[-]()
Sophora tetraptera[-]()
Sophora tomentosa L.[-]()
Sophora velutina var. zimbabweensis[-]()

분 자 식 

C₁₁H₁₄N₂O

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

190.247

녹 는 점 

155°C

생리학적효과 

Antiinflammatory agent. Shows psychoactive props. Has been used as respiratory stimulant in USSR. Common cause of poisoning of humans and animals by Cytisus laburnum. Toxicity:LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod).

굴 절 율 

[α]17 D = -119°( H2O)

CNMR_CHART 

(CDCl3) δ: 104.9(C1), 138.7(C2), 116.5(C3), 163.6(C4), 49.7(C6), 27.7(C7), 26.2(C8), 35.5(C9), 151.2(C10), 52.9(C11), 53.9(C13)

MASS_CHART 

GCM+= 190, m/z= 160, 148, 147, 146(100), 134, 109, 83, 44, 41

참고문헌 

· HR. Ing et al., J. Chem. Soc., 2195, 1931 · F. Bohlmann et al., Chem. Ber., 89, 792, 1956(uv,ir); 108, 1043, 1975(cmr) · PC. Ruenitz et al., J. Het. Chem., 14, 423, 1977(ms) · T. Satoshi et al., Phytochemistry, 30, 11, 3793, 1991 · Aldrich Library of 13C and 1H FT NMR Spectra, 1, 1324B (nmr) · HR. Ing, J. Chem. Soc., 2195, 1931; 2778, 1932 · WF. Cockburn et al., Can. J. Chem., 30, 92, 1952 · TT. Shakirov et al., Khim. Prir. Soedin., 6, 723, 1970; Chem. Nat. Compd. (Engl. Transl.), 6, 733, 1970 · AI. Ishbaev et al., Khim. Prir. Soedin., 8, 328, 1972; Chem. Nat. Compd. (Engl. Transl.), 8, 322, 1972 · TE. Monakhova et al., Khim. Prir. Soedin., 9, 59, 1973; Chem. Nat. Compd. (Engl. Transl.), 9, 52, 1973 · S. Ohmiya et al., Phytochemistry, 13, 643, 1016, 1974 · I. Murakoshi et al., Phytochemistry, 16, 1460, 1977; 21, 1470, 2385, 1982 · AA. Freer et al., Acta Cryst. C, 43, 1119, 1987 · R. Greinwald et al., Phytochemistry, 29, 3553, 1990 · K. Saito et al., Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, 32, 268, 1990 · R. Greinwald et al., Z. Naturforsch., C, 45, 1085, 1990 · AM. Gazaliev et al., Khim. Prir. Soedin., 27, 301, 1991; Chem. Nat. Compd. (Engl. Transl.), 27, 259, 1991 · G. Veen et al., Phytochemistry, 31, 3487, 1992 · Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, London, 12886, 1993