코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Columbamine

함유 천연물 

Coptis chinensis Franch.[](황련(黃連))
Coptis japonica (Thunb.) Makino[황련(Hwangn-yeon)](황련(黃連))
Coptis teeta[]()
Corydalis turtschaninovii Fa yanjusuo[]()
Corydalis yanhusuo W. T. Wang[](연호색(延胡索))
Nandina domestica Thunb.[남천(Nam-cheon)](남천죽자(南天竹子),남천죽엽(南天竹葉),남천죽근(南天竹根))

분 자 식 

C₂₀H₂₀NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

338.387

녹 는 점 

(Cl) 239-240°C

생리학적효과 

Butyrylcholinesterinase inhibitor; Anti-HIV activity. Antihypertensive agent. Possesses bactericidal, CNS depressant props.

UV_CHART 

(λmax, nm) (EtOH):(as chloride): 229(3.91), 268(3.87), 281sh(3.84), 350(3.82), 430(3.17)

HNMR_CHART 

(TFA,100 MHz) δ:7.70(s, H1), 7.03(s, H4), 9.56(s, H8), 8.07(d, 9, H11), 7.96(d, 9, H12), 8.47(s, H13), 4.07(s, 3-OMe), 4.30(s, 9-OMe), 4.18(s, 10-OMe)

참고문헌 

· MP. Cava et al., Lloydia, 28, 73, 1965 · JL. Beal et al., Lloydia, 39, 65, 1976; 39, 204, 1976(uv,ir) · A. Ikuta et al., Phytochemistry, 27, 7, 2143, 1988 · K. Jewers et al., J. Chem. Soc. Perkin Trans. 2, 1393, 1972 · M. Shamma et al., J. Nat. Prod., 41, 169, 1978(uv) · MP. Cava et al., J. Nat. Prod., 28, 73, 1965 · K. Jewers et al., J. Chem. Soc. Perkin 2, 1393, 1972(cmr) · S. Pavelka et al., Coll. Czech. Chem. Comm., 41, 3157, 1976(uv) · GT. Tan, J. Nat. Prod., 54, 143, 1991(anti-HIV activity)