코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Bulbocapnine

다른이름들 

N-Methyllaunobine 11-Hydroxy-10-methoxy-1,2-methylenedioxyaporphine

함유 천연물 

Corydalis decumbens (Thunb.) Pers.[좀현호색(Jom-hyeon-ho-saek)](하천무(夏天無))

분 자 식 

C₁₉H₁₉NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

325.368

녹 는 점 

198-199°C EtOH

생리학적효과 

Antihypertensive, cataleptic, sedative agent. Possesses adrenolytic props. In low doses depresses spinal motorneurone synaptic reflexes. Toxicity: LD50 (mus, scu) 195 mg/kg.

굴 절 율 

[α]20 D = +232° (C 0.92,CHCl3)

UV_CHART 

(λmax, nm) (EtOH):223(4.48), 235 sh(4.33), 269(4.16), 282 sh(4.12), 306(3.81)

HNMR_CHART 

(CDCl3) δ:6.64(s, H3), 6.83(s, H8,9), 3.92(s, OMe), 2.57(s, NMe), 5.95, 6.10(ea. d, 1, methylenedioxy)

MASS_CHART 

M+= 325, m/z= 324, 310(100), 282, 165, 152

참고문헌 

· MP. Cava et al., J. Org. Chem., 33, 2443, 1968 · H. Guinaudeau et al., J. Nat. Prod., 38, 275, 1975(uv,ms) · M. Tomita et al., Yakugaku Zasshi, 89, 737, 1969(pmr) · JM. Gulland et al., J. Chem. Soc., 1132, 1928 · ST. Lu et al., Yakugaku Zasshi, 92, 910, 1972; CA, 77, 101949m · A. Shafiee et al., J. Nat. Prod., 42, 174, 1979 · B. Ringdahl et al., J. Nat. Prod., 44, 80, 1981 · H. Guinaudeau et al., J. Nat. Prod., 48, 646, 1985 · H. Soicke et al., Arch. Pharm. (Weinheim, Ger.), 321, 149, 1988 · YC. Wu, Heterocycles, 29, 463, 1989 · B. Ribar et al., Acta Cryst. C, 47, 2612, 1991