코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Berberine

다른이름들 

5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benodioxolo[5,6-a]quinolizinium Berbericine Natural yellow 18 Umbellatine

함유 천연물 

Berberis soulieana[-]()
Chelidonium majus L.[]()
Coptis chinensis Franch.[](황련(黃連))
Coptis deltoidea C. Y. Cheng et Hsiao[](황련(黃連))
Coptis japonica (Thunb.) Makino[황련(Hwangn-yeon)](황련(黃連))
Coptis teeta[]()
Corydalis decumbens (Thunb.) Pers.[좀현호색(Jom-hyeon-ho-saek)](하천무(夏天無))
Corydalis yanhusuo W. T. Wang[](연호색(延胡索))
Juglans regia L.[-](핵도인(核桃仁))
Nandina domestica Thunb.[남천(Nam-cheon)](남천죽자(南天竹子),남천죽엽(南天竹葉),남천죽근(南天竹根))
Phellodendron amurense Rupr.[황벽나무(Hwang-byeok-na-mu)](황백(黃柏))
Phellodendron chinense Schneid.[](황백(黃柏),황벽(黃蘗))

분 자 식 

C₂₀H₁₈NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

336.371

녹 는 점 

(I-) 250(dec.)°C EtOH

생리학적효과 

Bitter stomachic. Antibacterial. Antimalarial, antipyretic. Pharmacol. extensively studied. Antiarrhythmic agent. .alpha.2-Adrenoceptor agonist. Cholinesterase, tyrosine decarboxylase and tryptophanase inhibitor. Shows a wide variety of pharmacol. effects including respiratory stimulation, transient hypotension. Antianaemic, anticonvulsant, antiinflammatory agent. Shows antibacterial and antifungal props. and some cytotoxic and antineoplastic activity. Possesses immunostimulant, sedative and antitrypanosomal activity. Of clinical use in treatment of gastrointestinal disorders, has been used for cholera and infantile diarrhoea. Toxicity: Adverse human effects including reduced body temperature. Can cause death by central paralysis. LD50 (mus, orl) 329 mg/kg. Sulfate trihydrate, (C20H18NO4)2.SO4.3H2O;LD50 in mice: 24.3 mg/kg i.p.

HNMR_CHART 

(CDCl3:CF3COOD= 5: 1,200 MHz) δ:7.39(H1), 6.83(H4), 3.24(H5), 4.88(H6), 9.54(H8), 7.90(H11), 7.88(H12), 8.34(H13), 6.07(OCH2O), 4.19(9-OMe), 4.07(10-OMe)

CNMR_CHART 

(CDCl3:CF3COOD= 5: 1,50 MHz) δ: 105.1(C1), 119.8(C1a), 148.6(C2), 151.0(C3), 108.5(C4), 129.8(C4a), 27.2(C5), 56.3(C6), 144.1(C8), 121.8(C8a), 144.1(C9), 150.5(C10), 126.9(C11), 123.1(C12), 133.5(C12a), 120.2(C13), 138.2(C13a), 102.3(OCH2O), 61.9(9-OMe), 56.7(10-OMe)

참고문헌 

· R. Janssen et al., Phytochemistry, 28, 2833, 1989(pmr,cmr) · JL. Beal et al., Lloydia, 39, 65, 1976; 39, 204, 1976(uv,ir) · T. Kametani et al., J. Chem. Soc.(C), 2036, 1969 · YN. Gupta et al., Nat. Appl. Sci. Bull., 26, 31, 1974; CA, 85, 90192 W · WH. Perkin et al., J. Chem. Soc., 127, 740, 1925 · RD. Haworth et al., J. Chem. Soc., 548, 1927 · V. Preininger et al., Coll. Czech. Chem. Comm., 35, 124, 1970 · K. Jewers et al., J. Chem. Soc. Perkin 2, 1393, 1972 · MM. Tadzhibaev et al., Khim. Prir. Soedin., 10, 48, 1974; Chem. Nat. Compd. (Engl. Transl.), 10, 42, 1974 · WN. Wu et al., J. Nat. Prod., 40, 384, 1977 · G. Berlin et al., Agents Actions, 14, 401, 1984 · M. Suffness et al., Alkaloids (N.Y.), 25, 191, 1985 · DS. Bhakuni et al., Alkaloids (N.Y.), 28, 78, 1986 · PL. Schiff, Alkaloids: Chem. Biol. Perspect., Wiley, N.Y., 5, 363, 1987 · G. Blasko et al., Heterocycles, 27, 911, 1988 · KK. Hui et al., Life Sci., 49, 315, 1991 · Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, London, 1341, 1993 · H. Ishii et al., Heterocycles, 37, 897, 1994 · YX. Wang et al., J. Cardiovasc. Pharmacol., 23, 716, 1994 · CM. Chen et al., J. Chromatogr., B: Biomed. Appl., 665, 117, 1995