코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Berberastine

다른이름들 

10-O-Methylthalidastine

함유 천연물 

Coptis chinensis Franch.[](황련(黃連))
Coptis deltoidea C. Y. Cheng et Hsiao[](황련(黃連))
Coptis japonica (Thunb.) Makino[황련(Hwangn-yeon)](황련(黃連))
Coptis teeta[]()
Nandina domestica Thunb.[남천(Nam-cheon)](남천죽자(南天竹子),남천죽엽(南天竹葉),남천죽근(南天竹根))

분 자 식 

C₂₀H₁₈NO₅

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

352.37

녹 는 점 

>300(as Iodide)°C

UV_CHART 

(λmax, nm) (H2O):(as Iodide); 228(4.61), 265(4.41), 345(4.37), 426(3.71)

HNMR_CHART 

(DMSO-d6) δ:4.08(3H, s, OMe-9), 4.12(3H, s, OMe-10), 4.7-5.3(3H, m, H5,6), 5.95-6.05(1H, m, OH), 6.20(2H, s, OCH2O), 7.16(1H, s, H4), 7.83(1H, s, H1), 8.02(1H, d, 9, H11), 8.24(1H, d, 9, H12), 9.01(1H, s, H8), 9.98(1H, s, H13)

참고문헌 

· SF. Duke et al., Tetrahedron, 31, 561, 1975 · MM. Nijland, Pharm. Weekbl., 96, 640, 1961; 98, 301, 1963 · I. Monkovic et al., Can. J. Chem., 43, 2017, 1965 · M. Shamma et al., J. Pharm. Sci., 57, 262, 1968 · MHA. Zarga et al., Tetrahedron Lett., 21, 3739, 1980 · A. Ikuta et al., J. Nat. Prod., 47, 189, 1984 · E. Napolitano et al., J. Chem. Soc. Perkin 1, 2565, 1987