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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
Atropine |
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다른이름들 |
alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester (dl-form)
dl-Hyoscyamine
dl-Tropyl tropate
dl-Tropine tropate |
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함유 천연물 |
Arctium lappa L.[우엉(U-eong)](우방자(牛蒡子),우방근(牛蒡根),대력자(大力子),서점자(鼠粘子),악실(惡實),악실경(惡實莖))
Atropa belladonna L.[벨라도나](전가초(顚茄草))
Datura alba Rumph.ex Nees[]()
Datura inoxia Mill.[-]()
Datura meteloides Dunal[털독말풀(Teol-dok-mal-pul)](양금화(洋金花),만타라자(曼陀羅子))
Datura stramonium L. var. stramonium[흰독말풀(Huin-dok-mal-pul)]()
Hyoscyamus niger L.[사리풀(Sa-ri-pul)](천선자(天仙子))
Lycium barbarum L.[](구기(枸杞))
Scopolia japonica Maxim.[미치광이풀(Mi-chi-gwang-i-pul)](동낭탕(東낭탕))
Scopolia lutescens Y.N.Lee[노랑미치광이풀(No-rang-mi-chi-gwang-i-pul)]() |
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분 자 식 |
C17H23NO3 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
289.378 |
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녹 는 점 |
114.5-115°C acetone |
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생리학적효과 |
Mydriatic, antispasmodic and cycloplegic agent. Smooth muscle relaxant. Used in preanaesthetic medication to prevent reflex brachycardia and bronchospasm and to decrease gland secretions. Reduces rigidity in parkinsonism. Antidote to poisoning with parasympathomimetic agents, e.g. nerve gases, organophosphorus insecticides. Cause of deliberate and accidental poisoning of humans and livestock. Nontoxic to some spp., e.g. rabbits. Reference material used in elemental microanalysis. Toxicity: Adverse human effects by ingestion, and other routes of administration, incl. dryness of the mouth, difficulty swallowing and thirst. Adverse ocular effects. Can cause death. Variable human lethal dose, but 100 mg can be fatal. LD50 (rat, orl) 500 mg/kg. Exp. reprod. and teratogenic effects. LD50 orally in rats: 750 mg/kg (Cahen, Tvede). Causes blurred vision, suppressed salivation, vasodilation, hyperpyrexia, excitement, agitation, and delirium LDLo(rbt, orl) 1450mg/kg. LD50(gpg orl) 1100mg/kg. |
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HNMR_CHART |
(CDCl3) δ:7.23(5H,aromatic protons), 4.95(1H,t,H3), 4.50(1H,br s,OH), 4.4-3.5(3H,m,-CH-CH2-OH), 2.95(2H,s,H1,5), 2.15(3H,s,NMe), 2.4-0.8(8H,m,CH2 in tropane skeleton) |
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CNMR_CHART |
(CDCl3,22.5 MHz) δ: 59.94, 36.50, 68.48, 36.31, 59.86, 25.71, 25.63, 40.41, 128.36, 129.58, 128.97, 136.90, 173.16, 55.11, 64.45 |
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참고문헌 |
· M. Ylinen et al., Planta Med., 2, 85, 1986
· DG. Spoerke et al., J. Emergency Med., 5, 5, 385, 1987
· VI. Stenberg et al., J. Het. Chem., 14, 225, 1977
· Y. Takeuchi et al., Chem. Pharm. Bull., 19, 2603, 1971(ir)
· HM. Fales et al., J. Am. Chem. Soc., 92, 1590, 1970(ms) |
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