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 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

(-)-alpha-Narcotine

다른이름들 

(1R,9S)-Narcotine 6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo-[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone (1R,9S-form)

함유 천연물 

Papaver somniferum L.[양귀비(Yang-gwi-bi)](앵속각(罌粟殼))

분 자 식 

C₂₂H₂₃NO₇

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

413.431

녹 는 점 

176°C EtOH

생리학적효과 

Antitussive agent, effective smooth muscle relaxant Toxicity: LD50 (mus, orl) 840 mg/kg.

굴 절 율 

[α]D = -200°(CHCl3)

HNMR_CHART 

(CDCl3,200 MHz) δ:2.55(3H,NMe), 3.86(3H,OMe), 4.03(3H,OMe), 4.09(3H,OMe), 4.41(1H,d), 5.59(1H,d), 5.94(methylenedioxy), 6.09(1H,d), 6.31(1H), 6.96(1H,d)

참고문헌 

· J. Staunton et al., J. Chem. Soc. Perkin Trans. I, 1147, 1975 · B. Proksa et al., Cesk. Farm., 40, 1, 34, 1991; CA, 115, 79000, Z · M. Shamma et al., J. Nat. Prod., 45, 105, 1982(ir,pmr) · M. Ohta et al., Chem. Pharm. Bull., 12, 1080, 1964 · T. Kametani et al., J. Chem. Soc. Perkin 1, 374, 1977 · MA. Al-Yahya et al., Anal. Profiles Drug Subst., 11, 407, 1982 · T. Shono et al., J. Org. Chem., 48, 1621, 1983 · DS. Moss et al., Acta Cryst. C, 40, 1960, 1984 · RHAM. Janssen et al., Phytochemistry, 29, 3331, 1990 · R. Porter et al., Mutagenesis, 7, 205, 1992