코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

(+)-Tetrandrine

다른이름들 

(+)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman

함유 천연물 

Aristolochia debilis Sieb.et Zucc.[](마두령(馬兜鈴))
Menispermum dauricum DC.[새모래덩굴(Sae-mo-rae-deong-gul)](편복갈근(편복葛根),편복갈(편복葛))
Stephania hernandifolia[]()
Stephania tetrandra S. Moore[](방기(防己))

분 자 식 

C₃₈H₄₂N₂O₆

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

622.768

녹 는 점 

218°C Et2O

생리학적효과 

Analgesic; antipyretic.Shows hypotensive and vasodilator props., gives exp. protection against myocardial infarction. Shows antineoplastic activity. Cytotoxic to KB cells, shows activity against Walker 256 carcinosarcoma and Ehrlich ascites in vivo. Most effective antineoplastic agent of the bisbenzylisoquinoline alkaloids. Shows antiinflammatory, antidiabetic and anaesthetic props. also possesses antiarrhythmic, antimicrobial and antimitotic props. Calcium channel antagonist. Both enantiomers and racemate reported to have antineoplastic activity. Toxicity: LD50 (mus, ipr) 41.3 mg/kg. Chronic administration causes liver necrosis. Lymphotoxin.

굴 절 율 

[α]21 D = +241.38° (C 0.87,CHCl3)

UV_CHART 

(λmax, nm) (MeOH):214(4.78), 283(3.91)

HNMR_CHART 

(CDCl3,60 MHz) δ:2.29(3H, s, NMe), 2.58(3H, s, NMe), 3.15(3H, s, OMe), 3.31(3H, s, OMe), 3.69(3H, s, OMe), 3.87(3H, s, OMe), 5.91-7.35(10H, m, ArH)

MASS_CHART 

M+= 622, m/z= 621, 607, 396, 395, 349, 335, 198.5, 198(100), 192, 190, 176, 175.5, 175, 174

참고문헌 

· D. Dwuama-Badu et al., Phytochemistry, 14, 2524, 1975(uv,ir,pmr,ms) · KP. Guha et al., J. Nat. Prod., 42, 1, 1979(uv,ir,pmr,ms) · GR. Chaudhry et al., J. Sci. Ind. Res., Sect. B, 17, 163, 1958 · SM. Kupchan et al., J. Pharm. Sci., 50, 164, 819, 1961 · IRC. Bick et al., J. Chem. Soc., 1896, 1961 · LR. Row et al., J. Sci. Ind. Res., Sect. B, 21, 581, 1962 · JR. Boissier et al., Ann. Pharm. Fr., 21, 767, 1963 · M. Tomita et al., Yakugaku Zasshi, 83, 190, 1963 · SR. Johns et al., Aust. J. Chem., 21, 1387, 1968 · J. Baldas et al., J. Chem. Soc. Perkin 1, 592, 1972 · SM. Kupchan et al., J. Org. Chem., 38, 1846, 1973 · AN. Tackie et al., J. Nat. Prod., 37, 1, 1974 · T. Yupraphat et al., Planta Med., 25, 315, 1974 · R. Verpoorte et al., Planta Med., 34, 274, 1978 · L. Koike et al., Tetrahedron Lett., 3765, 1979 · DS. Bhakuni et al., Phytochemistry, 19, 2347, 1980 · C. Moulis, J. Nat. Prod., 44, 101, 1981