코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Crotonoside

다른이름들 

Isoguanosine 9-beta-D-Ribofuranosylisoguanine 6-Amino-9-beta-D-ribofuranosyl-9H-purin-2(1H)-one

함유 천연물 

Croton tiglium Linne[파두](파두(巴豆))

분 자 식 

C₁₀H₁₃N₅O₅

화학족 분류 

질소화합물(nitrogen);

분 자 량 

283.246

녹 는 점 

243-245(dec)°C H2O

생리학적효과 

Incorporated into mammalian nucleic acids. Stimulates cyclic AMP incorporation into brain tissue, inhibitor of inosine monophosphate pyrophosphonylase and glutamic acid dehydrogenase.

굴 절 율 

[α]26 D = -71° (C 1.1,0.1M NaOH)

UV_CHART 

(λmax, nm) (H2O):293(11,100), 247(8,930); (0.5N HCl): 283(12,700), 235(6,140); (0.05N NaOH): 285(10,550), 251(6,890)

HNMR_CHART 

((CD3)2SO/D2O) δ:3.56(1H, dd, 2.8, 12.3), 3.66(1H, dd, 2.8, 12.3), 3.98(1H, m), 4.11(1H, dd, 2.7, 4.9), 4.50(1H, m), 5.67(1H, d, 6.4), 7.97(1H, s)

CNMR_CHART 

((CD3)2SO) δ: 61.63, 70.71, 72.98, 85.94, 87.69, 109.67, 138.07, 152.59, 156.03, 160.61

참고문헌 

· E. Cherbuliez et al., Helv. Chim. Acta, 15, 464, 978, 1932 · K. Divakar et al., J. Chem. Soc. Perkin Trans. I, 771, 1991(uv,pmr,cmr) · JR. Spies, J. Am. Chem. Soc., 61, 350, 1939 · J. Davoll, J. Am. Chem. Soc., 73, 3174, 1951 · A. Yamazaki et al., Chem. Pharm. Bull., 16, 2172, 1968 · K. Miura et al., Chem. Pharm. Bull., 23, 2064, 1975 · J. Sepiol et al., Z. Naturforsch., C, 37, 361, 1976 · FA. Fuhrmann et al., Science (Washington, D.C.), 212, 557, 1981 · V. Nair et al., J. Org. Chem., 50, 406, 1985 · JW. Chern et al., J. Org. Chem., 56, 4213, 1991 · F. Seela et al., Helv. Chim. Acta, 77, 622, 1994 · F. Seela et al., Helv. Chim. Acta, 78, 1843, 1995 · L. De Napoli et al., J. Chem. Soc. Perkin 1, 15, 1995