코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Trilobine

함유 천연물 

Cocculus trilobus (Thunb.) DC.[댕댕이덩굴(Daeng-daeng-i-deong-gul)](목방기(木防己),방기(防己))

분 자 식 

C₃₅H₃₄N₂O₅

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

562.672

녹 는 점 

235-239°C Me2CO

생리학적효과 

Convulsive agent. Shows in vitro antitumour activity against HeLa-S3 cells. Toxicity: LD50 500 mg/kg.

굴 절 율 

[α]20 D = +305° (C 1.26,CHCl3)

UV_CHART 

(λmax, nm) (EtOH):275 sh(3.96), 288(3.97), 305(3.81)

HNMR_CHART 

(CDCl3,60 MHz) δ:1.73(1H, br s, NH), 2.60(3H, s, NMe), 2.33-3.80(14H, br, H-methlyene, methine), 3.88(3H, s, ArOMe), 3.98(3H, s, ArOMe), 6.20-7.50(10H, m, H-aromatic)

MASS_CHART 

M+= 562, m/z= 561, 335, 168

참고문헌 

· KP. Guha et al., J. Nat. Prod., 42, 1, 1979 · S. Dasgupta et al., J. Nat. Prod., 42, 399, 1979(uv,ir,pmr,ms) · H. Kondo et al., Yakugaku Zasshi, 532, 465, 1926; 542, 265, 1927; CA, 21, 2699 · M. Tomita et al., Yakugaku Zasshi, 83, 190, 1963; CA, 59, 3971h · Y. Inubushi et al., Yakugaku Zasshi, 83, 288, 1963; CA, 59, 5212h · J. Baldas et al., J. Chem. Soc. Perkin Trans. 1, 592, 1972(ms) · IRC. Bick et al., J. Chem. Soc. Perkin Trans. 1, 2884, 1972(pmr) · VJ. Tripathi et al., Indian J. Chem., Sect. B, 14, 62, 1976 · Y. Inubushi et al., Chem. Pharm. Bull., 25, 1636, 1977 · MA. El-Kawi et al., J. Nat. Prod., 47, 459, 1984