코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Tetrahydropalmatine

다른이름들 

Rotundine Gindarine Caseanine Corydalis B

함유 천연물 

Coptis teeta[]()
Corydalis yanhusuo W. T. Wang[](연호색(延胡索))
Papaver somniferum L.[양귀비(Yang-gwi-bi)](앵속각(罌粟殼))
Stephania tetrandra S. Moore[](방기(防己))

분 자 식 

C₂₁H₂₅NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

355.438

녹 는 점 

151-151.5°C MeOH

생리학적효과 

Analgesic, sedative and hypnotic agent (hypnotic activity exceeds that of Morphine .shows strong papaverine-like activity

굴 절 율 

[α]20 D = +288.5° (C 2,EtOH)

HNMR_CHART 

(CDCl3,60 MHz) δ:6.82(2H), 6.76(1H), 6.62(1H, aromatic protons), 3.87(3H), 3.85(6H), 3.84(3H,OMe)

CNMR_CHART 

δ: 150.0, 147.8, 145.0, 129.5, 128.3, 127.7, 126.8, 123.8, 111.7, 111.4, 109.1, 60.2, 59.4, 56.2, 56.0, 53.9, 51.5, 36.1, 29.0

MASS_CHART 

M+= 256, m/z= 190, 164, 144, 121

참고문헌 

· MP. Cava et al., J. Org. Chem., 33, 2785, 1968 · E. Spath et al., Can. J. Chem., 54, 2252, 1976 · T. Kametani et al., J. Chem. Soc.(C), 530, 1967(ir,pmr) · SG. Pyne et al., J. Org. Chem., 55, 1932, 1990(nmr,ms) · C. Tani et al., Chem. Lett., 1081, 1975 · D. Tourwe et al., Org. Magn. Reson., 9, 341, 1977(pmr) · NS. Narasimhan et al., Tetrahedron, 39, 1975, 1983 · S. Wang et al., Yiyao Gongye, 19, 444, 1988; CA, 110, 173517s · RA. Hussain et al., Heterocycles, 29, 2257, 1989(nmr) · K. Orito et al., Org. Prep. Proced. Int., 21, 309, 1989 · SV. Kessar et al., J. Org. Chem., 57, 6716, 1992 · B. Ribar et al., Acta Cryst. C, 49, 1691, 1993