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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
Stylopine |
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다른이름들 |
Tetrahydrocopitisine
6,7,12b,13-Tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoline |
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함유 천연물 |
Chelidonium majus L.[]()
Corydalis turtschaninovii Fa yanjusuo[]() |
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분 자 식 |
C19H17NO4 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
323.352 |
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녹 는 점 |
217-218°C |
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생리학적효과 |
Antipsychotic and neuroleptic activity in mice and rats. |
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UV_CHART |
(λmax, nm) (MeOH):289.4 |
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HNMR_CHART |
δ:2.64(2H, m, H5,6), 2.79 & 3.22(2H, qd, H13), 3.1(2H, m, H5,6), 3.52, 4.09(2H, q, H8), 3.56(1H, dd, H14), 5.92(2H, s, OCH2O), 5.92, 5.96(2H, q, OCH2O), 6.59(1H, s, ArH), 6.63(1H, d, ArH), 6.68(1H, d, ArH), 7.3(1H, s, ArH) |
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CNMR_CHART |
δ: 2.96, 36.5, 51.2, 52.9, 59.8, 100.7, 101.1, 105.5, 106.7, 108.4,116.9, 121.0, 127.8, 128.6, 130.8, 145.0, 146.0, 146.2 |
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참고문헌 |
· E. Spath et al., Ber., 64, 1131, 1931
· G. Dai-Ho et al., J. Org. Chem., 53, 5113, 1988(uv,ir,pmr,cmr)
· PW. Jeffs et al., J. Org. Chem., 40, 644, 1975
· AR. Battersby et al., J. Chem. Soc. Perkin Trans. 1, 1140, 1975
· SK. Bhattacharya et al., Arzneim.-Forsch., 26, 2187, 1976
· N. Takao et al., Chem. Pharm. Bull., 24, 3185, 1976
· NS. Narasimhan et al., Tetrahedron, 39, 1975, 1983
· DS. Bhakuni et al., Alkaloids (N.Y.), 28, 95, 1986
· E. Taborska et al., Coll. Czech. Chem. Comm., 51, 2232, 1986
· M. Chrzanowska, J. Nat. Prod., 58, 401, 1995 |
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