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▣ 천연물에서 분리된 개별유효성분 레코드 등록정보 |
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성 분 명 |
(-)-Scopolamine |
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다른이름들 |
alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azabicyclo-[3.3.1.0(2,4)]non-7-yl-ester
(-)-Scopoline tropate
(-)-Escopolamina
(-)-Hyoscine
(-)-Oscine tropate |
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함유 천연물 |
Datura alba Rumph.ex Nees[]()
Datura inermis Jacq.[-]()
Datura inoxia Mill.[-]()
Datura meteloides Dunal[털독말풀(Teol-dok-mal-pul)](양금화(洋金花),만타라자(曼陀羅子))
Datura stramonium L. var. stramonium[흰독말풀(Huin-dok-mal-pul)]() |
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분 자 식 |
C17H21NO4 |
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화학족 분류 |
알칼로이드(alkaloid); |
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분 자 량 |
303.361 |
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생리학적효과 |
Toxicity: Adverse ocular effects. Absorbed through skin. Human CNS effects when used therapeutically (esp. drowsiness). Psychotic effects when administered transdermally. LD50 (mus, orl) 1275 mg/kg. Exp. reprod. and teratogenic effects. Hydrobromide trihydrate: LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick). |
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굴 절 율 |
[α]20 D = -18°( EtOH) |
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HNMR_CHART |
(CDCl3,300 MHz) δ:7.29(H meta), 7.21(H ortho), 7.18(H para), 4.98(H3'), 4.3(H3a), 3.77(H3b), 3.08(H5'), 2.94(H1'), 3.37(H6'), 2.70(H7'), 3.72(H2), 2.42(H9'), 2.08(H4'ax), 1.55(H4'eq), 1.99(H2'ax), 1.31(H2'eq) |
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CNMR_CHART |
(CDCl3,75 MHz) δ: 171.8(C1), 135.8(C ipso), 129.0(C meta), 128.1(C orhtho), 127.9(C para), 66.9(C3'), 64.0(C3), 57.9(C5'), 57.8(C1'), 56.4(C6'), 56.0(C7'), 54.4(C2), 42.2(C9'), 31.0(C4'), 30.8(C2') |
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MASS_CHART |
M+= 303 |
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참고문헌 |
· C. Sarazin et al., Magn. Reson. Chem., 29, 291, 1991(nmr)
· Y. Yamada et al., Plant Cell. Rep., 1, 101, 1982
· L. Witte et al., Planta Med., 5, 390, 1986
· SR. Johns et al., J. Chem. Soc., Chem. Commun., 458, 1965(pmr)
· HM. Fales et al., Arch. Mass Spectral Data, 2, 654, 1971
· L. Simeral et al., Org. Magn. Reson., 6, 226, 1974(cmr) |
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