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 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Narceine

다른이름들 

6-[[6-{2-(Dimethylamino)ethyl}-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid

함유 천연물 

Papaver somniferum L.[양귀비(Yang-gwi-bi)](앵속각(罌粟殼))

분 자 식 

C₂₃H₂₇NO₈

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

445.474

녹 는 점 

176-178(as trihydrate)°C MeOH/Et2O

생리학적효과 

Respiratory stimulant, antitussive agent. No analgesic activity. Antihypertensive agent. Intestinal smooth muscle stimulant.

UV_CHART 

(λmax, nm) (MeOH):220(4.38), 271(4.15), 288 sh(3.99)

HNMR_CHART 

(CD3OD,80 MHz) δ:2.75(6H,s,NMe), 2.85-3.30(4H,m,H5,6), 3.78(9H,br s,3xOMe), 4.20(2H,s,H14), 5.80(2H,s,-O-CH2-O-), 6.35(1H,s,H4), 6.88(1H,d,9,H12), 7.45(1H,d,9,H11)

CNMR_CHART 

(CD3OD,20 MHz) δ: 199.44, 170.45, 155.00, 147.74, 143.78, 141.94, 135.50, 130.50, 130.04, 123.76, 119.27, 110.45, 103.97, 100.60, 60.70, 59.41, 55.84, 57.21, 41.81, 28.61

MASS_CHART 

M+= 445, m/z= 427, 58(100)

참고문헌 

· G. Blasko, J. Org. Chem., 47, 880, 1982(uv,pmr) · W. Kloumltzer et al., Monatsh, Chem., 103, 1210, 1972 · K. Prabir et al., Phytochemistry, 28, 7, 2002, 1989(uv,ir,pmr,cmr,ms) · M. Shamma et al., J. Prod. Nat., 45, 105, 1982 · P. Rabe et al., Annalen, 377, 223, 1910 · CR. Addinall et al., J. Am. Chem. Soc., 55, 1202, 2153, 1933 · LH. Briggs et al., Anal. Chem., 29, 904, 1957 · R. Baggio et al., Acta Cryst. C, 52, 703, 1996