코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Morphine N-oxide

다른이름들 

Genomorphine Meconium N-oxide 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol N-oxide Morfine N-oxide

함유 천연물 

Papaver somniferum L.[양귀비(Yang-gwi-bi)](앵속각(罌粟殼))

분 자 식 

C₁₇H₁₉NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

301.345

녹 는 점 

272-273°C

HNMR_CHART 

(CDCl3/CD3OD,60 MHz) δ:7.00(H1), 6.78(H2), 6.00(H7), 5.45(H8), 5.30(H5), 3.85(NMe)

MASS_CHART 

M+= 301, m/z= 285(100), 284, 283, 271, 228, 227, 226

참고문헌 

· JD. Phillipson et al., Phytochemistry, 15, 1297, 1976(pmr,ms) · FI. Carrol et al., J. Org. Chem., 41, 996, 1976(cmr) · DMS. Wheeler et al., J. Am. Chem. Soc., 89, 4494, 1967(ms) · J. Fridrichsons et al., Tetrahedron Lett., 2887, 1968 · MR. Fennessy et al., Eur. J. Pharmacol., 8, 261, 1969 · T. Kametani et al., J. Chem. Soc.(C), 3030, 1969 · GG. de Angelis et al., Tetrahedron, 25, 5099, 1969 · RLH. Heimans et al., J. Pharm. Pharmacol., 23, 831, 1971 · AR. Battersby et al., Tetrahedron Lett., 1873, 1975 · E. Bye, Acta Chem. Scand., Ser. B, 30, 549, 1976 · AC. Allen et al., J. Org. Chem., 48, 3951, 1983 · JE. Toth et al., J. Org. Chem., 52, 473, 1987 · JE. Toth et al., J. Org. Chem., 53, 4694, 1988 · KA. Parker et al., J. Am. Chem. Soc., 114, 9688, 1992 · CY. Hong et al., J. Am. Chem. Soc., 115, 11028, 1993