코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Menisine

다른이름들 

Tetrandrine; (+)-form, Isomorph 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; (+)-form, Isomorph

함유 천연물 

Cocculus trilobus (Thunb.) DC.[댕댕이덩굴(Daeng-daeng-i-deong-gul)](목방기(木防己),방기(防己))

분 자 식 

C₃₈H₄₂N₂O₆

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

622.768

녹 는 점 

152°C

생리학적효과 

Toxicity: LD50 (mus, ipr) 41.3 mg/kg. Chronic administration causes liver necrosis. Lymphotoxin.

굴 절 율 

[α]20 D = +290°

MASS_CHART 

M+= 622

참고문헌 

· SM. Kupchan et al., J. Pharm. Sci., 50, 164, 819, 1961 · AW. McKenzie et al., Aust. J. Chem., 6, 180, 1953 · DAA. Kidd et al., J. Chem. Soc., 669, 1954 · GR. Chaudhry et al., J. Sci. Ind. Res., Sect. B, 17, 163, 1958 · F. v. Bruchhausen et al., Arch. Pharm. (Weinheim, Ger.), 293, 454, 1960 · IRC. Bick et al., J. Chem. Soc., 1896, 1961 · LR. Row et al., J. Sci. Ind. Res., Sect. B, 21, 581, 1962 · JR. Boissier et al., Ann. Pharm. Fr., 21, 767, 1963 · M. Tomita et al., Yakugaku Zasshi, 83, 190, 1963 · SR. Johns et al., Aust. J. Chem., 21, 1387, 1968 · J. Baldas et al., J. Chem. Soc. Perkin Trans. 1, 592, 1972 · SM. Kupchan et al., J. Org. Chem., 38, 1846, 1973 · AN. Tackie et al., J. Nat. Prod., 37, 1, 1974 · T. Yupraphat et al., Planta Med., 25, 315, 1974 · D. Dwuma-Badu et al., Phytochemistry, 14, 2524, 1975 · R. Verpoorte et al., Planta Med., 34, 274, 1978 · DS. Bhakuni et al., Phytochemistry, 19, 2347, 1980 · C. Moulis, J. Nat. Prod., 44, 101, 1981 · G. Wang et al., Life Sci., 56, 295, 1994 · QY. Liu et al., J. Pharmacol. Exp. Ther., 273, 32, 1995