코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Matrine ((+)-form)

다른이름들 

Matridin-15-one ((+)-form) Lupanidine ((+)-form)

함유 천연물 

Sophora alopecuroides L.[-]()
Sophora chrysophylla Seem.[-]()
Sophora chrysophylla spp. glabrata (Gray) Chock[-]()
Sophora flavescens Solander ex Aiton[고삼(Go-sam)](고삼(苦蔘),고삼실(苦蔘實),수괴(水槐),지괴(地槐))
Sophora griffithii[-]()
Sophora japonica L.[회화나무(Hoe-hwa-na-mu)](괴화(槐花),괴각(槐角),괴지(槐枝),괴엽(槐葉),괴각자(槐角子),괴교(槐膠),괴근백피(槐根白皮),괴백피(槐白皮),괴실(槐實),괴윤(槐潤),괴자(槐子),괴자인(槐子仁),괴조(槐條),수궁괴(守宮槐))
Sophora jaubertii[-]()
Sophora longesmen[-]()
Sophora lupinoides L.[-]()
Sophora macrocarpa[-]()
Sophora microphylla[-]()
Sophora moorcroftiana (Wall.) Benth.ex Bak.[-]()
Sophora pachycarpa[-]()
Sophora spyostriata[-]()
Sophora stenophylla Gray[-]()
Sophora subprostrata Chun et T. Chen[광두근](산두근(山豆根))
Sophora tetraptera[-]()
Sophora tomentosa L.[-]()

분 자 식 

C₁₅H₂₄N₂O

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

248.371

녹 는 점 

77°C

생리학적효과 

Has antiulcer, antineoplastic and antibacterial props.. Toxicity: LD50 (rat, ipr) 125 mg/kg.

굴 절 율 

[α]15 D = +40.9°( H2O)

HNMR_CHART 

(C6D6,400 MHz) δ:4.73(H17beta), 3.54(H11alpha), 3.03(H17alpha), 2.55(H10alpha), 2.49(H2alpha), 2.37(H14alpha), 2.06(H14alpha), 1.68(H6beta), 1.64(H10beta), 1.62(H2beta), 1.50(H3alpha), 1.45(H5beta), 1.44(H4alpha,12alpha), 1.33(H9alpha), 1.22(H13beta), 1.18(H8alpha,beta), 1.07(H13alpha), 1.03(H3beta,9beta), 0.98(H7beta), 0.96(H4beta), 0.82(H12beta)

CNMR_CHART 

(CDCl3) δ: 57.2(C2), 20.7(C3), 27.1(C4), 35.3(C5), 63.7(C6), 41.3(C7), 26.4(C8), 21.2(C9), 57.2(C10), 53.1(C11), 27.8(C12), 18.9(C13), 32.8(C14), 43.2(C17)

MASS_CHART 

GCM+= 248, m/z= 247(100), 219, 205, 177, 150, 136, 98, 96, 41

참고문헌 

· F. Bohlmann et al., Chem. Ber., 108, 1043, 1975(cmr) · NC. Gonnella et al., Magn. Reson. Chem., 26, 185, 1988(pmr) · S. Okuda et al., Chem. Pharm. Bull., 13, 482, 1965(ir) · NS. Vul'dson et al., Khim. Geterotsikl. Soedin., 251, 1974(ms) · F. Bohlmann et al., Chem. Ber., 91, 2176, 2189, 1958 · HR. Schutte et al., Annalen, 685, 194, 1965 · L. Mandell et al., J. Am. Chem. Soc., 87, 5234, 1965 · A. Aslanov et al., CA, 67, 71108, 1967 · DD. Kamalitdinov et al., Khim. Prir. Soedin., 5, 409, 1969; Chem. Nat. Compd. (Engl. Transl.), 5, 340, 1969 · R. Kojima et al., Chem. Pharm. Bull., 18, 2555, 1970 · A. Ueno et al., Chem. Pharm. Bull., (footnote), 23, 2560, 1975 · K. Morinaga et al., Chem. Pharm. Bull., 26, 2483, 1978 · BT. Ibragimov et al., Khim. Prir. Soedin., 15, 416, 1979; Chem. Nat. Compd. (Engl. Transl.), 15, 368, 1979 · FJ. Leeper et al., Can. J. Chem., 59, 106, 1981 · RE. Negrete et al., Bol. Soc. Chil. Quim., 27, 263, 1982 · BT. Ibragimov et al., Khim. Prir. Soedin., 18, 71, 1982; Chem. Nat. Compd. (Engl. Transl.), 18, 66, 1982 · R. Negrete et al., Phytochemistry, 22, 2069, 1983 · BA. Abdusalamov, Khim. Prir. Soedin., 20, 3, 1984; Chem. Nat. Compd. (Engl. Transl.), 20, 1, 1984 · T. Sakamoto et al., Chem. Pharm. Bull., 34, 2018, 1986