코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Laudanosine ((S)-(+)-form)

다른이름들 

N-Methyltetrahydropapaverine Laudanine methyl ether

함유 천연물 

Papaver somniferum L.[양귀비(Yang-gwi-bi)](앵속각(罌粟殼))

분 자 식 

C₂₁H₂₇NO₄

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

357.454

녹 는 점 

84-88°C EtOH

생리학적효과 

Toxicity:Convulsive agent, strong tetanic poison, acting on the extrapyramidal system and mesencephalon.

굴 절 율 

[α]21 D = +82.5° (C 0.4,EtOH)

UV_CHART 

(λmax, nm) :207 sh(4.89), 232(4.17), 282(3.77)

HNMR_CHART 

(CDCl3,60 MHz) δ:2.50(3H, s, NMe), 3.55(3H, s, OMe), 3.78(3H, s, OMe), 3.81(6H, s, OMe)

참고문헌 

· SK. Roy et al., Tetrahedron, 22, 1335, 1966(uv) · M. Konda et al., Chem. Pharm. Bull., 23, 1025, 1975(ir,pmr,ms); 25, 69, 1977 · IW. Elliott, J. Het. Chem., 7, 1229, 1970 · V. Preininger, Alkaloids (N.Y.), 15, 207, 1975 · SP. Singh et al., J. Het. Chem., 15, 541, 1978 · S. Takano et al., Chem. Comm., 769, 1982 · Z. Czarnocki et al., Can. J. Chem., 64, 2205, 1986 · RE. Gawley et al., Tetrahedron Lett., 29, 301, 1988 · L. Gottlieb et al., J. Org. Chem., 55, 5659, 1990 · GM. Coppola, J. Het. Chem., 28, 1769, 1991 · DL. Comins et al., Tetrahedron Lett., 32, 2995, 1991 · S. Takano et al., Heterocycles, 35, 47, 1993 · Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, London, 1200, 1993 · M. Kitamura et al., J. Org. Chem., 59, 297, 1994