코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Isotrilobine ((+)-form)

다른이름들 

Homotrilobine N,O-Dimethylcocsoline O-Methylcocsuline

함유 천연물 

Cocculus trilobus (Thunb.) DC.[댕댕이덩굴(Daeng-daeng-i-deong-gul)](목방기(木防己),방기(防己))
Stephania hernandifolia[]()

분 자 식 

C₃₆H₃₆N₂O₅

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

576.699

녹 는 점 

217-218°C Me2CO

생리학적효과 

Antitumour activity against HeLa-S3 cells and Ehrlich ascites.

굴 절 율 

[α]D = +325°(C 0.41, CHCl3)

UV_CHART 

(λmax, nm) (MeOH):234(4.56), 287(3.65)

MASS_CHART 

M+= 576, m/z= 575, 349(100), 335, 319, 175

참고문헌 

· SF. Hussain et al., Tetrahedron, 40, 2513, 1984(uv,ms) · VJ. Tripathi et al., Indian J. Chem., Sect. B, 14, 62, 1976(uv,pmr,ms) · H. Kondo et al., Yakugaku Zasshi, 532, 461, 1926; CA, 21, 2699 · M. Tomita et al., Yakugaku Zasshi, 79, 977, 1959; 83, 190, 1963; CA, 53, 22042i; 59, 3971h · Y. Inubushi et al., Yakugaku Zasshi, 83, 282, 1963; CA, 59, 5212b · NK. Hart et al., Aust. J. Chem., 25, 2289, 1972 · J. Baldas et al., J. Chem. Soc. Perkin Trans. 1, 592, 1972(ms) · IRC. Bick et al., J. Chem. Soc. Perkin Trans. 1, 2884, 1972 · Y. Inubushi et al., Chem. Pharm. Bull., 25, 1636, 1977 · IRC. Bick et al., Heterocycles, 16, 2105, 1981 · M. Leboeuf et al., Plant. Med. Phytother., 16, 280, 1982