코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Harman

다른이름들 

Aribine Loturine Passiflorine Zygofabagine 1-Methyl-beta-carboline 1-Methyl-9H-pyrido[3,4-b]indole

함유 천연물 

Commelina communis L.[닭의장풀(Dak-ui-jang-pul)](압척초(鴨척草))
Kochia scoparia (L.) Schrad. var. scoparia[댑싸리(Daep-ssa-ri)](지부자(地膚子))
Polygala tenuifolia Willd.[원지(Won-ji)](원지(遠志))
Tribulus terrestris L.[남가새(Nam-ga-sae)](자질려(刺질藜),백질려(白질藜),사원질려(沙苑질藜),질려자(질藜子))

분 자 식 

C₁₂H₁₀N₂

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

182.227

녹 는 점 

237-238°C

생리학적효과 

Cytotoxic intercalating agent. Plant growth and enzyme inhibitor. Sedative. Toxicity: LD50 (mus, ipr) 50 mg/kg. LDLo(rbt, scu) 200mg/kg.

UV_CHART 

(λmax, nm) (MeOH):234, 287, 347

HNMR_CHART 

(CDCl3,60 MHz) δ:2.80(3H, s, Me-1), 7.60-7.20(3H, aromatic protons), 7.84 & 8.36(ea.1H, d, 5, H3,4), 8.10(1H, d, 6, H5), 9.12(1H, br s, NH)

CNMR_CHART 

(DMSO-d6,75 MHz) δ: 142.04, 140.26, 137.42, 134.42, 127.67, 126.76, 121.59, 121.02, 119.07, 112.51, 111.84, 20.44

MASS_CHART 

M+= 182, m/z= 182(100), 154

참고문헌 

· T. Kametani et al., J. Chem. Soc.(C), 1006, 1968 · CJ. Pouchert et al., The Aldrich Library of FT NMR spectra, Ed. I, 165B, 1993 · K. Yomosa et al., Agric. Biol. Chem., 51, 921, 1987 · RT. Coutts et al., Org. Mass Spect., 3, 879, 1970 · Aldrich Library of FT-IR Spectra, 1st edn., 2, 682A(ir) · E. Bachli et al., Helv. Chim. Acta, 40, 1167, 1957 · B. Abdusamalov et al., CA, 63, 3314b, 1965 · AD. Lashkhi et al., Izv. Akad. Nauk Gruz. SSR, Ser. Biol., 1, 238, 1975 · JD. Phillipson et al., J. Chromatogr., 105, 163, 1975 · BH. Han et al., Arch. Pharmacol. Res., 9, 21, 1986 · J. Hardiman et al., Bioorg. Chem., 15, 213, 1987 · F. Bracher et al., Annalen, 1335, 1993(nmr) · H. Seki et al., Chem. Pharm. Bull., 41, 1169, 1993(nmr) · P. Rocca et al., Tetrahedron, 49, 3325, 1993