코스넷:::::화장품원료:::::

 ▣ 천연물에서 분리된 개별유효성분 레코드 등록정보

성 분 명 

Fangchinoline

다른이름들 

6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol

함유 천연물 

Menispermum dauricum DC.[새모래덩굴(Sae-mo-rae-deong-gul)](편복갈근(편복葛根),편복갈(편복葛))
Stephania hernandifolia[]()
Stephania tetrandra S. Moore[](방기(防己))

분 자 식 

C₃₇H₄₀N₂O₆

화학족 분류 

알칼로이드(alkaloid);

분 자 량 

608.741

녹 는 점 

240-242 (dec.)°C Et2O

생리학적효과 

Shows good in vitro antineoplastic activity against HeLa cells. Antifibrogenic, antiinflammatory props..

굴 절 율 

[α]18 D = +250°( CHCl3)

UV_CHART 

(λmax, nm) (MeOH):236 sh(4.51), 282(4.01)

HNMR_CHART 

(CDCl3) δ:2.33(3H, NMe), 2.59(3H, NMe), 3.35(3H, OMe), 3.77(3H, OMe), 3.93(3H, OMe), 6.06-7.23(10H, aromatic H)

MASS_CHART 

M+= 608, m/z= 607, 471, 417, 416, 382, 381, 367, 350, 335, 321, 192, 191, 174, 168

참고문헌 

· AN. Tackie et al., Lloydia, 37, 1, 1974(uv,ir,pmr,ms) · S. Sato et al., Patent-Japan Kokai Tokkyo Koho-63, 179, 878, 1988; CA, 110, 29089, M · SM. Kupchan et al., J. Pharm. Sci., 50, 164, 819, 1961 · SR. Johns et al., Aust. J. Chem., 21, 1387, 1968 · IRC. Bick et al., J. Chem. Soc. Perkin 1, 2884, 1972 · J. Baldas et al., J. Chem. Soc. Perkin 2, 592, 1972(ms) · SM. Kupchan et al., J. Org. Chem., 38, 1846, 1973 · T. Yupraphat et al., Planta Med., 25, 315, 1974 · H. Guinaudeau et al., Planta Med., 27, 304, 1975; 29, 54, 1976 · J. Siwon et al., Phytochemistry, 20, 323, 1981 · R. Verpoorte et al., J. Nat. Prod., 45, 582, 1982 · M. Lavault et al., J. Chem. Res., Synop., 248, 1985 · M. Lavault et al., Chem. Pharm. Bull., 34, 1148, 1986 · JKH. Ma et al., Exp. Lung Res., 17, 1061, 1991 · K. Nakamura et al., Planta Med., 58, 505, 1992